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Cartilage Oligomeric Matrix Protein (COMP) leaks continously from the joint into the blood. In patients with Rheumatoid arthritis and/or Osteoarthritis a blood test can predict the risk of chronic joint disease at an early stage. |
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Recent data suggest the existence of different phenotypic subsets of RA at clinical onset and elevated serum COMP levels should be interpreted in relation to this new approach |
In recent years, data have been published to suggest that anti-CCP positive and anti-CCP negative RA constitute two different phenotypic manifestations of RA with respect to both clinical prognosis and underlying disease mechanisms. |
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